Biologic Treatments for Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a chronic autoimmune disease that wreaks havoc on the joints, causing irreversible damage, deformities, and bone erosion.

The traditional treatments for RA, such as disease-modifying anti-rheumatic drugs (DMARDs), nonsteroidal anti-inflammatory drugs (NSAIDs), and steroids, have their limitations and come with unwanted side effects.

DMARDs may slow down the progression of RA, but they can also harm the liver and lead to severe lung infections. NSAIDs may provide temporary relief from symptoms, but they don’t halt joint damage. Steroids can alleviate pain and inflammation, but their long-term use can bring about significant side effects.

However, there’s a game-changing treatment option for rheumatoid arthritis known as biologic infusion therapy. This innovative approach involves the use of biologics, which are medications derived from living organisms and cells, to modify the immune system’s functioning and reduce inflammation. During infusion therapy, the medication is administered slowly through an intravenous (IV) line over a specific period.

What are Biologics?

Biologics, also known as biological products, encompass a wide range of substances including sugars, proteins, nucleic acids, cells, and tissues. These remarkable compounds are derived from natural sources and can be produced using advanced biotechnology.

One fascinating aspect of biologics is protein engineering, which involves creating new proteins or modifying existing ones to achieve specific functions. In essence, biologics can be seen as engineered proteins derived from genes.

When it comes to medical applications, biologics play a crucial role in treating inflammatory conditions. By targeting the actions of specific proteins involved in inflammation, they effectively disrupt the chemical messages sent by the immune system, thereby preventing a chain reaction of inflammatory responses. This targeted approach allows biologics to provide relief and improve the quality of life for individuals suffering from such conditions.

Three main categories of biologics can be used to treat inflammatory bowel disease

The first category is anti-tumor necrosis factor (TNF) biologics, such as Remicade® and Humira®, which work by blocking a protein that causes inflammation in the intestine. The second category is anti-integrins, which target proteins involved in cell adhesion and migration, important for the inflammatory response.

Lastly, there are anti-interleukin (IL) 12/23 biologics, which block the activity of specific cytokines involved in the immune response. These biologics have revolutionized the treatment of inflammatory bowel disease, providing better clinical responses and safety compared to traditional treatments.

Biologic Drugs for RA

Treatments for rheumatoid arthritis (RA) have come a long way, and biologic drugs have revolutionized the field.

These specialized medications, such as Abatacept (Orencia), Adalimumab (Humira), Anakinra (Kineret), Belimumab (Benlysta), Canakinumab (Ilaris), Certolizumab (Cimzia), Etanercept (Enbrel), Golimumab (Simponi, Simponi Aria), and  Infliximab (Remicade), work by honing in on specific components of the immune response.

By targeting key chemicals, cells, or proteins, they effectively manage the symptoms of RA and slow down the progression of the disease. Unlike traditional medications, biologics solely focus on the immune system, making them highly effective in reducing inflammation in the joints.

While they may not always be the first line of treatment, they have proven to be a game-changer for many individuals, providing relief and improving their quality of life.

Benefits of Biologic Infusion Therapy 

Biologic infusion therapy offers a viable solution for individuals suffering from chronic autoimmune diseases like rheumatoid arthritis. This treatment involves the administration of biologic drugs through an IV drip, specifically targeting the immune system to combat inflammation associated with these conditions.

The advantages of biologic infusion therapy are manifold, including enhanced treatment results, improved adherence to treatment plans, and a more convenient and soothing experience for patients. For those chronic rheumatic patients who do not respond to oral medications or injections, biologic infusion therapy presents an exceptional treatment alternative.

Biosimilars 

Biosimilars, the newer iterations of biologic drugs, closely resemble the original drugs regarding safety, purity, and potency. These remarkable medications are employed to address a range of conditions, such as rheumatoid arthritis (RA), at a more affordable price compared to their original counterparts.

Regulatory agencies like the U.S. Food and Drug Administration (FDA) have approved biosimilars, aiming to enhance competition, expand accessibility, and reduce costs associated with biologic specialty drugs.

Conclusion

It’s crucial for patients to feel empowered when it comes to discussing biologic infusion therapy with their healthcare providers. By engaging in open and thorough conversations, patients can gain a comprehensive understanding of various aspects of this treatment, such as the process, potential benefits, and any concerns they may have.

Numerous studies have highlighted the importance of these discussions, as they enable patients to make well-informed decisions about their treatment. Moreover, these conversations provide patients with valuable insights into the treatment process, potential side effects, and the expected therapeutic effects of biologic infusion therapy.

Patients should also feel at ease when asking questions about the specific biologic medication they will receive, the infusion process, and how it may impact their daily lives. By fostering open communication with their healthcare providers, patients can actively participate in decision-making and feel supported throughout their treatment journey.